1st
SYMPOSIUM ON THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF
SCHIZOPHRENIA AND BIPOLAR DISORDER
AGENDA
FRIDAY,
NOVEMBER 3, 1995
8:00:
Continental Breakfast/Sign In
8:30: Welcome and
Introduction. Robert H. Yolken, M.D., Director,
Stanley Neurovirology Laboratory of the Johns Hopkins University
School of Medicine.
8:40: Viruses and
Psychiatric Disease–Does the Connection Make Sense? Robert H.
Yolken.
SESSION
I: PRESENTATIONS FROM THE STANLEY NEUROVIROLOGY LABORATORY OF THE
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
9:00:
Viral
Transcription Factor RNAs Are Differentially Expressed in the
Brains of Individuals With Schizophrenia. Frances Yee,
Ph.D., Stanley Fellow, Johns Hopkins University.
9:15:
Metabolites
of Clozapine Inhibit the Replication of Neurotropic Viruses. Lorraine V.
Brando, Ph.D., The Stanley Neurovirology Laboratory, Johns
Hopkins University.
9:30:
A
Comparison of Cytokine Transcripts from Selected Brain Areas
Between Individuals with Schizophrenia and Controls. Linda Bobo,
Ph.D., The Stanley Neurovirology Laboratory, Johns Hopkins
University.
9:45:
Brain
Libraries Indicate Differential RNA Expression in Schizophrenia
and Bipolar Disease. Nancy Johnston, Ph.D., Stanley
Fellow, Johns Hopkins University.
10:00:
Assessment
of Genomic Difference Between Liver and Brain of a Schizophrenic
Patient. Naderah Jafari, Ph.D., Stanley Fellow,
Johns Hopkins University.
10:15:
BREAK
10:30:
Infection
of Neural Cells with Brains from Individuals with Schizophrenia. Indra Dé,
Ph.D., Stanley Fellow, Johns Hopkins University.
10:45:
Analysis
of Genomic DNA from Patients with Schizophrenia. Yeping Sun,
Ph.D., Stanley Fellow, Johns Hopkins University.
KEYNOTE
SPEAKER
11:00:
Effects
of Viruses on Limbic System Neurons and Neurotransmittters:
Implications for Schizophrenia and Bipolar Disorder. Krister
Kristensson, M.D., Ph.D., Department of Neurosciences, Karolinska
institute, Stockholm, Sweden.
12:00:
LUNCH
SESSION
II: ETIOLOGIC AGENTS OF PSYCHIATRIC DISEASE–INFECTION AND
IMMUNITY
1:30:
Retroviral
Antibodies in Schizophrenics: Possible Immunomodulation by
Psychotropic Drugs. Darrenn J. Hart, Tulane University School
of Medicine.
1:45:
Maternal
Influenza, Obstetric Complications and Schizophrenia. Padraig Wright,
Pfizer Central Research, UK.
2:00:
Mapping
of a Herpes Simplex Virus Genetic Element Involved in
Neurovirulence and Neuroinvasiveness. Jeng-Yang Ling,
Baylor College of Medicine.
2:15:
IgM
Antibodies to Eight Common Neurotropic Viruses in the Serum
Samples of Schizophrenic Patients and Controls from South India. V. Ravi, NIMHNS,
India.
2:30:
HSV1
in Brain: An Environmental Risk Factor in Alzheimer’s Disease. Ruth F. Itzhaki,
University of Manchester, UK.
2:45:
Retinoic
Acid Response Element DNA Motifs in Viruses May Affect Retinoid
Cascade in Schizophrenia. Ann B. Goodman, Nathan S. Kline
Institute.
3:00:
Relationship
of Anti-Streptococcal and Anti-Neuronal Antibodies in Patients
with Tourette’s Syndrome and Obsessive Compulsive Disorder. Daniel M.
Tucker, Yale University School of Medicine.
3:15:
BREAK
3:30:
State
Dependent Immune Disturbances in Schizophrenia. Daniel P. van
Kammen, Department of Veterans Affairs Medical Center,
Pittsburgh, PA.
3:45:
Prediction
of Relapse from Changes in Cytokine and Antibody Production in
Schizophrenia. Rohan Ganguli, Western Psychiatric
Institute and Clinic.
4:00:
Evaluation
of 6 Measures of Central Nervous System Immune Activation in CSF
or Patients with Schizophrenia. George R.
Heninger, Yale University School of Medicine.
4:15:
Acute
Phase Proteins in Affective Illness. Mady
Hornig-Rohan, Depression Research Unit, University of
Pennsylvania.
4:30:
Enumeration
of CD34+ Hematopoietic Stem Cells in Schizophrenic Individuals
Receiving Clozapine. Henrietta Kulago, National
Institute of Mental Health.
4:45:
The
Immune System Alterations in Psychiatric Disorders: The Causes of
Appearance and the Mechanisms of Development. Galina
Kolyaskina, National Mental Health Research Center, Russia.
DINNER
BREAK
FRIDAY
EVENING
SESSION
III: BIOLOGY AND EPIDEMIOLOGY OF BORNA DISEASE VIRUS
7:00:
Introduction. Robert H.
Yolken, M.D.
7:05:
Overview
of the Biology of Borna Virus As Applied to Psychiatric Diseases. Kathryn Carbone,
M.D., The Johns Hopkins University, Division of Infectious
Diseases, Department of Medicine.
7:15:
Experimental
Borna Disease as a Model for Immune-mediated Abnormalities in the
Brain. Lothar Stitz, Institut für Virologie,
Germany.
7:30:
Severe
Neurological Symptoms in Mice Infected with Borna Disease Virus. Peter Staeheli,
University of Freiburg, Germany.
7:45:
Quantitative
Correlation of Viral Induced Damage to the Hippocampus and
Spatial Learning and Memory Deficits. Kathryn M.
Carbone, The Johns Hopkins University.
8:00:
Prefrontal
Cortex Dysfunction in Rats Infected with Borna Disease Virus. W. Ian Lipkin,
University of California, Irvine.
8:15:
Detection,
Isolation and Molecular Characterization of Human BDV. Daniel
Gonzalez-Dunia, The Scripps Research Institute.
8:30:
Schizophrenia
and Borna Disease – Clinical Relationships in a Monozygotic Twin
Study Cohort. Royce W. Waltrip III, Maryland
Psychiatric Research Center.
8:45:
OPEN MICROPHONE PRESENTATIONS AND DISCUSSIONS
SATURDAY,
NOVEMBER 4, 1995
SESSION
I: INFECTIOUS AGENTS AND PSYCHIATRIC DISEASE — POTENTIAL
MECHANISMS
KEYNOTE
SPEAKER
9:00:
Virus
Infection of Neurons, Disordered CNS Function and Resultant
Neuropsychiatric Disease. Michael B. A. Oldstone, M.D.,
The Scripps Research Institute.
9:45:
The
Immunopathogenesis of Virus-Induced Myocarditis. Noel R. Rose,
M.D., Ph.D., The Johns Hopkins University.
10:15:
Viral
Models for Persistent Neurological Infection. Diane Griffin,
M.D., Ph.D, The Johns Hopkins University.
10:45:
BREAK
11:00: Geographic
Correlation of Schizophrenia and Ixodes Tick-Borna Viruses. James S. Brown,
M.D., U.S. Military Academy.
11:15:
Simultaneous
Analysis of Multiple DNA Suspects From Twins Discordant for
Schizophrenia. Cassandra L. Smith, Boston University.
11:30:
Calcium
Dysregulation in Major Mood Disorders. Martha M.
Coetzee, Uniformed Services University of the Health Sciences.
11:45:
Viral
Research in Schizophrenia: Phenomenological Considerations. William T.
Carpenter, University of Maryland School of Medicine.
12:00
LUNCH/POSTER PRESENTATIONS
Possible
Suppression of Herpes Simplex Virus Infections with Lithium
Carbonate. Jay D. Amsterdam, Greg Maislin,
University of Pennsylvania Medical Center.
Viral
Etiology and Seasonality of Schizophrenic Births in Barbados. Ram Rao Malesu,
K. McKenzie, R. Murray, Institute of Psychiatric, Genetics
Sections, London.
A
7-Year Prospective Study of Long-Term Lithium Effect on Affective
and Labial Herpes Recurrences in Bipolar Patients. Janusz K.
Rybakowski and Jay D. Amsterdam, Department of Adult Psychiatry,
University of Medical Sciences, Poland and University of
Pennsylvania Medical Center.
Seroepidemiological
Studies of Prenatal Viral Infection and Adult Schizophrenia. Alan S. Brown,
New York State Psychiatric Institute.
SESSION
II: ANIMAL MODELS OF PSYCHIATRIC DISEASES
1:00:
A
New Foamy Retrovirus From An Orang-Utan With Encephalopathy. Myra O. McClure,
St. Mary’s Hospital Medical School, U.K.
1:15:
Virus-Induced
Pathology in the Developing Hippocampus May Involve Disruption of
Inhibitory Circuits. Brad D. Pearce, Emory University
School of Medicine.
1:30:
Altered
Brain FYN Kinase in a Murine AIDS. Yoshitatsu Sei,
NIDDK, NIH.
1:45:
Surrogate
Markers’ for Encephalopathy in the SIV-Infected Rhesus Monkey. Lee E. Eiden,
National Institute of Mental Health.
2:00:
Attempts
to Passage a Transmissible Growth Agent From CSF of Schizophrenic
Patients to Neonatal Mice. Janice R. Stevens, Oregon Health
Sciences University.
2:15:
Localization
of Viral Message in Brains of Cats Exposed Postnatally to Bovine
Viral Diarrhea Virus. Susan E. Bachus, National
Institute of Mental Health.
2:30:
Decreased
Levels of A Lipid in the Brain Frontal Lobe in Patients With
Schizophrenia. Subrato Chatterjee, The Johns Hopkins
University School of Medicine.
2:45:
OPEN MICROPHONE PRESENTATIONS AND DISCUSSION
3:15:
Meeting
Summary and Conclusions. E. Fuller Torrey, M.D., National
Institute of Mental Health.
Individual abstracts
can be found on “Abstracts 1995” page.