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TOXOPLASMA GONDII AND SCHIZOPHRENIA E. FULLER TORREY AND ROBERT H. YOLKEN Recent epidemiologic studies indicate that infectious agents may contribute to some cases of schizophrenia.  In animals infection with Toxoplasma gondii can alter behavior and neurotransmitter function.  In humans, acute infection with T gondii can produce psychotic symptoms similar to those displayed by persons with […]

Archives of General Psychiatry 60:466-472, 2003   ASSOCIATION OF SERUM ANTIBODIES TO HERPES SIMPLEX VIRUS 1 WITH COGNITIVE DEFICITS IN INDIVIDUALS WITH SCHIZOPHRENIA Faith B. Dickerson, John J Boronow, Cassie Stallings, Andrea E. Origoni, Inna Ruslanova, Robert H. Yolken Background:  Cognitive deficits are a characteristic feature of schizophrenia and contribute to the profound disabilities with

The L1 Retrotransposon–A Heavy Load on the Human Genome JD Boeke   We have learned an enormous amount recently abut the mechanism and biology of one of the major components of the human genome, the L1 (LINE) retrotransposon.  This remarkable element is likely responsible, directly or indirectly, for about one third of our genome by

GENE-ENVIROMENTAL INTERACTIONS IN HUMAN BRAIN DISEASES NOVEMBER 8 AND 9TH, 2004 JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE STANLEY MEDICAL RESEARCH INSTITUTE TURNER BUILDING TILGMAN ROOM    MONDAY, NOVEMBER 8, 2004  Morning Session Chaired by Dr. Christopher Ross  8:30    WELCOME AND INTRODUCTION             J. Raymond DePaulo, Michael Knable, E. Fuller Torrey             Department of Psychiatry, Johns

HERV-K Polymorphisms in Human Populations.    Jennifer F. Hughes and John M. Coffin Department of Molecular Biology and Microbiology, Tufts University, Boston MA     Human endogenous retroviruses (HERVs) are a potential source for the generation of genetic diversity in the human genome.  While the vast majority of these elements are fixed in the genome

A Espinosa and LP Villarreal   When introduced into ES cells of a blastocyct, polyomavirus (Py) T-Ag results in mice mosaic for T-Ag but otherwise essentially normal.  It has been reported that SV40 T-Ag does not inhibit differentiation of F9 EC cells, but did inhibit endogenous retrovirus (IAP) production.  We therefore sought to determine if

Analysis of the Kinetics of Latent HIV-1 Present in the Resting CD4+ T-Lymphocytes of HIV-1-Infected Children Treated with Highly Active Antiretroviral Therapy D Persaud, T Pierson, C Ruff, K Chadwick, J Margolick, A Ruff, N Hutton, RF Silicano Human immunodeficiency virus type 1 (HIV-1) persists in a latent state in the resting CD4+ T lymphocytes

To explore the contribution of infectious exposure to schizophrenia, we determined the levels of several antibodies to infectious agents in blood samples collected in a randomized double-blind 52 week clinical trial in China.  The sample included 160 first-episode schizophrenia patients and 60 normal controls balanced in distribution of age (28 ±7), gender (53% male vs.

CENTRAL NERVOUS SYSTEM AND SYSTEMIC QUINOLINIC ACID IN SCHIZOPHRENIA LD Bobo*, RH Yolken, EF Torrey, JD Paltan-Ortiz, MM Herman, NC Briggs, H Velasco, M Zito, MP Heyes Stanley Research Foundation, NAMI, Washington DC Immunologic marker elevations in schizophrenia have been reported. Quinolinic acid (QUIN), a potential neurotoxic product of immune-activated macrophages and microglia, has been

COMPARATIVE IMMUNOVIROLOGICAL INVESTIGATIONS OF HHV-6, HHV-7, AND HHV-8 IN MULTIPLE SCLEROSIS (MS), AND OTHER NEUROLOGICAL DISORDERS (OND), AND HEALTHY DONORS (HD) *D.V. Ablashi1,2, J. Friedman3, G. Pearson2, J. Zabriskie3, and J.E. Whitman1 1Advanced Biotechnologies Inc., Columbia, MD; 2Georgetown Univ Sch of Med, Washington DC; 3Lab of Clin Microbiology/Immunology, Rockefeller Univ New York, NY Previous reports