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STATISTICAL ANALYSES OF GENOMIC AND PROTEOMIC MEASUREMENTS IN HUMAN POSTMORTEM BRAIN TISSUE Dawn Dhavale, Stanley Medical Research Institute Researchers run the risk of introducing confounding variables unless consideration is given to matching tissue samples prior to investigation.  Of particular interest to researchers working with postmortem brain tissue are the affects of tissue pH, post-mortem interval, […]

DEEP WHITE MATTER ABNORMALITIES ON MRI ARE LINKED TO WINTER BIRTHS IN BIPOLAR PATIENTS P.B. Moore*, A. H. Young, I.N. Ferrier. Department Psychiatry, Newcastle University, Newcastle Upon Tyne, United Kingdom Introduction: Recently it has been established that bipolar patients, show winter/early spring birth excess. Although white matter abnormalities are found three times more frequently in

ANTIMICROBIAL AGENTS – POTENTIAL ROLE IN HUMAN PSYCHIATRIC DISEASES Robert H. Yolken, Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine There is a growing consensus that most diseases which are prevalent in the human population are complex disorders caused by the interaction between genetic and environmental determinants.  I hypothesize that schizophrenia and

POSTER     AMINO ACIDS METABOLIC ABNORMALITIES IN SCHIZOPHRENIA   Dmitri Tkachev1,3, Michael L. Mimmack1,3, Margaret M. Ryan1,3, Matt Wayland2, Tom Freeman2, Maree J. Webster4, Robert H. Yolkne5, and Sabine Bahn1,3 1Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK; 2UK Human Genome Mapping Project Resource Centre, Hinxton, Cambridge CB10 1SB, UK; 3Department of Psychiatry,

Antibodies to Infectious Agents in Individuals with Recent Onset Schizophrenia F. Markus Leweke, Christoph W. Gerth, Dagmar Koeth, Joachim Klosterkötter, Inna Ruslanova, Bogdana Kriovgorsky, E. Fuller Torrey, Robert H. Yolken Eur Arch Psychiatry Clin Neurosci 254: 4-8, 2004   Abstract We investigated the levels of antibodies to infectious agents in the serum and cerebral spinal

FAILURE TO DETECT BORNA DISEASE VIRUS p24 AND P40 mrna IN 60 AUTOPSY BRAIN SAMPLES OF THE STANLEY FOUNDATION BRAIN COLLECTION K. Ikeda*, S. Haga, Y.Motoi, T. Aizawa, K. Arima. Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Tokyo, Japan There is evidence suggesting an association of Borna Disease Virus (BDV) with certain psychiatric

DNA Methylation of HTR2A, DRD2 & RELN Genes Promoters and CpG rich areas in Schizophrenia.     Hamid Mostafavi Abdolmaleky, M.D.1,2,6, Sam Thiagalingam, Ph.D.3, Cassandra L. Smith, Ph.D. 4 , Stephen V.Faraone, Ph.D.2,5, Kunag-hung Cheng, MS. 3 ,Rahim Shafa M.D.7, Stephen Glatt Ph.D.1,2 , William S Stone, Ph.D. 1,2, and Ming Tsuang, M.D.1,2,,5,8,9   1Department of

MOLECULAR SYSTEMATICS OF TOXOPLASMA GONDII AND RELATED COCCIDIA: EXPANDING THE RANGE OF DISTINGUISING CHARACTERS FOR TAXONOMY, SYSTEMATICS AND DIAGNOSTICS Within the group of apicomplexan parasites broadly recognized as the coccidian, there is a limited range of morphological characters that can be used to distinguish species and even fewer characters that one can use to infer

THE EPIDEMIOLOGY OF SEVERE PSYCHIATRIC DISORDERS: IS IT TIME TO PUT THE CAT OUT? It is known that some infectious agents can cause brain diseases indistinguishable from schizophrenia and manic-depressive illness.  Epidemiological aspects, including winter-spring birth, urban birth, and migration as risk factors, are also compatible with an infectious cause.  Pet cats are known to

DOES BORNA DISEASE VIRUS CAUSE NEUROPSYCHIATRIC DISORDERS? K. Bechter, S. Herzog, R. Schò ttler. Dept. Psychiatry II University of Ulm, Germany. Borna diseases (BD) with it’s typical clinical course in horses and sheep is restricted to Germany, Switzerland and Austria. However, antibodies against Borna disease virus (BDV) can be detected worldwide. A role of BDV