4th SYMPOSIUM ON
THE NEUROVIROLOGY AND NEUROIMMUNOLOGY OF SCHIZOPHRENIA AND
BIPOLAR DISORDER
NOVEMBER 5 – 7, 1998
BETHESDA, MARYLAND
AGENDA
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ABSTRACT
Thursday, November 5, 1998
8:00 Continental Breakfast and Check-In
8:30: Welcome and Introduction
Robert H. Yolken, Director of the Stanley Division of
Developmental Neurovirology, Johns Hopkins University, Baltimore,
MD
SESSION I: PRESENTATIONS FROM THE STANLEY
FOUNDATION
8:40: Detection of
Retroviral RNA in the CSF of Individuals with Schizophrenia
Håkan Karlsson, Stanley Division of Developmental
Neurovirology, Johns Hopkins University, Baltimore, MD
9:00: In Vitro Analysis of
Cerebral Spinal Fluids From Cases of First Break Psychoses
Lorraine Jones-Brando, Stanley Division of Developmental
Neurovirology, Johns Hopkins University, Baltimore, MD
9:20: Determination of
Reverse Transcriptase (RT) Activity in Clinical and Post-Mortem
Samples From Individuals with Schizophrenia and Bipolar Disorder
Frances Yee, Stanley Division of Developmental Neurovirology,
Johns Hopkins University, Baltimore, MD
9:40: Protein Alterations
in the Postmortem Frontal Lobes of Individuals with Severe
Psychiatric Disorders
Nancy Johnston, Stanley Division of Developmental
Neurovirology, Johns Hopkins University, Baltimore, MD
10:10: Simultaneous
Analysis of Expression Levels of Many Genes in Post-Mortem Brain
Tissue From Individuals With Schizophrenia and Bipolar Disease
Kia Faridi, Stanley Division of Developmental Neurovirology,
Johns Hopkins University, Baltimore, MD
10:30: Quinolinic Acid and
Psychiatric Diseases
Linda Bobo, National Institute of Mental Health, Washington
DC
10:50: Update on the
Stanley Foundation Schizophrenia Treatment Network
Michael B. Knable, Stanley Foundation, Bethesda, MD
11:10: The Stanley Foundation
Brain Bank: A Progress Report
Maree J. Webster, Stanley Foundation Research Programs,
Bethesda, MD
11:30: Membrane Fatty Acid
Metabolism and Schizophrenia
Wayne S. Fenton, Stanley Treatment Program at Chestnut Lodge,
Rockville, MD
SESSION II: VIROLOGY OF BRAIN DISORDERS
1:20: Studies on
MS-Related Sequences Identified by Amplicon-Based RDA From
Affected Members of Monozygotic Twin Pairs Discordant for
Schizophrenia
Shiva M. Singh, University of Western Ontario, London,
Ontario, Canada
1:40: Oligoclonal
Expansion of T Cells In the Brain of Children with AIDS
Emilia L. Oleszak, Fels Institute, Temple University,
Philadelphia, PA
2:00: Isolation of
Non-Host Nucleic Acids From Viliuisk Encephalomyelitis
Irina Alexeeva, Baltimore Research & Education
Foundation, Baltimore, MD
2:20: Comparative
Immunovirological Investigations of HHV-6, HHV-7, and HHV-8 in
Multiple Schlerosis (MS), Other Neurological Disorders (OND), and
Healthy Donors (HD)
Gregory V. Williams, Advanced Biotechnologies Inc., Columbia,
MD
2:40: Selective Targeting
of Habenular, Thalemic Midline and Monaminergic Neurons by
Neurotropic Influenza A Virus
Krister Kristensson, Karolinska Institute, Stockholm, Sweden
3:00 Reversible
Encephalopathy Following Exposure to Estuarine Waters Containing
Pfeisteria-Like Organisms
Christopher Bever, University of Maryland School of Medicine,
Baltimore, MD
3:20: Prenatal Human
Influenza Viral Infection in Mice Decreases the Expression of
Reelen in the Neonatal Cortex and Hippocampus
S.H. Fatemi, University of Minnesota Medical School,
Minneapolis, MN
3:40: Neural Biopsies From
Patients with Schizophrenia: Testing the Neurodevelopmental
Hypothesis In Vitro
John McGrath, Queensland Centre for Schizophrenia Research,
Wolston Park Hospital, Wacol, Australia
4:00: Regulation of Herpes
Simplex Virus Latency in Neurons in Culture
Lewis I. Pizer, University of Colorado Health Sciences,
Denver, CO
4:20: Molecular Analysis
of Schizophrenia and Bipolar Disorder by cDNA Expression Assay
Alex Chenchik, Clontech Laboratories Inc., Palo Alto, CA
SESSION III: POSTER SYMPOSIUM
Levels of Leptin During Treatment With Antipsychotic Drugs
Thomas Pollmächer, Max Planck Institute of Psychiatry,
Munich, Germany
Levels of Cytokines and Soluble Cytokine Receptors In the Course
of Treatment With Antidepressants
Dunja Hinze-Selch, Max Planck Institute of Psychiatry,
Munich, Germany
Loci of the Human pMCH Genes: Antisense Expression and Potential
for Homologous Recombination
Christine Miller, University of Colorado,
Denver, CO
Immunological Alterations in Major Depression Are Not Caused by
Antidepressant Medication
Marion Peters, University of Lübeck, Germany
of Untreated Psychosis Is Associated With a Poor Treatment
Response In Schizophrenia
Silke Bachmann, University of Heidelberg,
Heidelberg, Germany
Resonance Imaging Correlates of Duration of Untreated Psychosis
in Schizophrenia
Silke Bachmann, University of Heidelberg, Heidelberg, Germany
T Cells Are Clonally Expanded in the Spinal Cord of TMEV-Infected
Mice
Emilia L. Oleszak, Temple University School of Medicine,
Philadelphia, PA
CD3+ T-Cell Infiltrates in HIV-1-Associated CNS Disease in
Children
Emilia L. Oleszak, Temple University School of Medicine,
Philadelphia, PA
Lymphocytes in Patients WIth Glioblastoma Multiforme Contain
Oligoclonal Populations of T-Cells
Chris D. Platsoucas, Temple University
School of Medicine, Philadelphia, PA
for Ganciclovir Therapy in a Schizophrenic Patient
W. John Martin, Center for Complex Infectious Diseases,
Rosemead, CA
for Proteins with Polyglutamine Expansions in the Stanley
Foundation Brain Collection
Alan H. Sharp, Dept. of Psychiatry and
Behavioral Sciences, Johns Hopkins University, Baltimore, MD
Acid Decarboxylase (GAD) Autoantibody Positivity in Schizophrenia
Eileen Kemether, Mount Sinai School of
Medicine, New York, NY
Prevalence of Psychoses in Genetic Isolate?
Joseph W. Eaton, UPMC, Pittsburgh, PA
A Potential Alternative Medicine for Neuropsychiatric Disorders
Guoqiang Xing, Uniformed Services University of the Health
Sciences, Bethesda, MD
the Genes Affected by Schizophrenia Using DNA Micro-Array
Yang Qiu, Lawrence Berkeley National Lab, Berkeley, CA
Expression of Neural Cell Adhesion Molecule in Schizophrenia
Marquis P. Vawter, NIDA Addiction Research Center, Baltimore,
MD
(A Homo Sapiens Specific Retroposon) is Homologous to cDNA from
Post-Mortem Brain in Schizophrenia and to Two Loci n the
Xq21.3/Yp Block Linked to Handedness and Psychosis
Heui-Soo Kim, Department of Psychiatry,
Warneford Hospital, University of Oxford, United Kingdom
FRIDAY, NOVEMBER 6, 1998
8:00: Continental Breakfast
SESSION I: PERINATAL FACTORS AND
PSYCHIATRIC DISEASES
A. What We Can Learn from the
Prospective Perinatal Cohort (CPP) Study
8:30: Introduction
E. Fuller Torrey, Executive Director, Stanley Foundation,
Bethesda, MD
8:40: Infection,
Inflammation, Cytokines and Cerbral Palsy
Karin Nelson, National Institute of Neurological and
Communicative Disorders and Stroke, Bethesda, MD
9:10: Viruses, Fetal
Hypoxia and Subsequent Schizophrenia: A Direct Test of Infectious
Agents Using Prenatal Sera
Stephen L. Buka, Harvard School of Public Health, Boston, MA
9:40: Prospective Studies
of Neurodevelopmental Influences in Schizophrenia
Tyrone D. Cannon, Department of Psychology, University of
Pennsylvania, Philadelphia, PA
10:10: A New Approach to Design
and Data Analysis for CPP-Based Studies that Make Use of Sera,
and Experience with Recent Laboratory Analysis of CPP Sera
Matthew P. Longnecker, National Institute of Environmental
Health, Research Triangle Park, NC
B. Perinatal Factors and Psychiatric
Diseases
10:50: Deep White Matter
Abnormalities on MRI Are Linked to Winter Births in Bipolar
Patients
Peter Brian Moore, Newcastle University, United Kingdom
11:10: Season of Birth and
Schizophrenia: A Systematic Review and Meta-Analysis of Data From
the Southern Hemisphere
John McGrath, Queensland Centre for Schizophrenia Research,
Wolston Park Hospital, Wacol, Australia
11:30: Fetal Mild
Ventriculomegaly Detected In Utero by Ultrasound: A Risk
Factor for Schizophrenia?
John Gilmore, University of North Carolina, Chapel Hill, NC
PLENARY SPEAKER
1:30: Virus-Immune
Interactions In the Pathogenesis of Theiler’s Virus Demyelinating
Disease
Raymond P. Roos, University of Chicago Pritzker School of
Medicine, Chicago, IL
SESSION II: IMMUNOLOGY OF BRAIN DISEASES
2:30: Immunomodulatory
Effects of Psychotropic Drugs
Dunja Hinze-Selch, Max Planck Institute of Psychiatry,
Munich, Germany
3:00: Effects of
Granulocyte Colony-Stimulating Factor on Sleep in Human
Andreas Schuld, Max Planck Institute of Psychiatry, Munich,
Germany
3:20: Interferon Gamma in
Schizophrenia–An Overview
Matthias Rothermundt, University of Lübeck, Germany
3:40: Immune Alterations in
Postpartum Depression and Maternity Blues
Michael Maes, Clinical Research Center for Mental Health,
Belgium
4:00: Altered Alterations
of B Cell Activation in CSF of Schizophrenic Patients
Norbert Müeller, University of Munich, Germany
4:20: Viral and Immune
Hypotheses In Schizophrenia: An Epigenetic Perspective
Art Petronis, Clarke Institute of Psychiatry, Toronto,
Ontario, Canada
4:40: What Does Disease
Discordance Mean in Monozygotic Twins?
Cassandra Smith, Boston University, Boston, MA
BREAK
6:00: Poster Viewing (Wine, Cheese and
Light food)
SESSION III: SYMPOSIUM ON BORNA INFECTIONS
7:00: Developmental Brain
Injury Associated with Abnormal Social behaviors in Neonatally
BDV-Infected Rats: A Model for Autism
Kathryn M. Carbone, Food and Drug Administration, Rockville,
MD
7:20: Does Borna Disease Virus
Cause Neuropsychiatric Disorders?
Karl Bechter, Dept. Psychiatry II, University of Ulm, Germany
7:50: Borna Disease Virus and
the Brain
Juan Carlos de la Torre, The Scripps Research Institute,
LaJolle, CA
8:20 POSTER PRESENTATIONS
of Borna Disease Virus (BDV) RNA in the Peripheral Leukocytes of
French Subjects: Preliminary Results
Marie-Edith Lafron, Virology Laboratory,
Bordeaux2-Victor Segalen University, France
to Detect Borna Disease Virus p24 and p40 mRNA in 60 Autopsy
Brain Samples of the Stanley Foundation Brain Collection
Kazuhiko Ikeda, Tokyo Institute of
Pyschiatry, Tokyo, Japan
Immunoassay for Measurement of Anti-Borna Disease Virus p40/p24
Antibody in Animal and Human Sera
K. Yamaguchi, Kumamto University School of
Medicine, Japan
Sensitivity Detection of Neurotropic Viruses in Postmortem Brain
Tissue by In Situ PCR and In Situ RT-PCR
Regina W. Einsiedel, Ruprecht-Karls-Univesitat, Heidelberg,
Germany
Cerebrospinal Fluid Filtration As
Experimental Treatment In a Case of Borna Disease
Virus-Encephalitis-Related Schizophrenia
Karl Bechter, Dept. Psychiatry II University of Ulm, Germany
SATURDAY, NOVEMBER 7, 1998
8:00: Continental Breakfast
SESSION I: ISSUES IN PSYCHIATRIC DISEASES
9:00: Update on The Epidemiology of
Psychiatric Diseases-Should You Put Out the Cat at Night
E. Fuller Torrey, Stanley Foundation, Bethesda, MD
9:30: Differential
Display Idnetifies Novel Targets for the Actions of Mood
Stabilizing Agents Lithium (LI) and Valproate (VPA)
Husseini K. Manji, Molecular Pathophysiology Program, WUS School
of Medicine
PLENARY SPEAKER
10:00: Retroviral Elements
Associated with Superantigens and Neurotoxins: Learnings From Our
Research in Multiple Sclerosis and Possible Avenue of Research in
Neurological Diseases
Herve Perron, bioMérieux, S.A., Lyon, France
11:00: SUMMARY AND CONCLUSIONS
Robert H. Yolken, M.D., Director, Stanley Division of
Developmental Neurovirology, Johns Hopkins University School of
Medicine, Baltimore, MD
Last revised on 05 July 2000.
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